The 20 Best Progressive Osseous Heteroplasia Doctors Near Me in Staten Island, NY

Progressive osseous heteroplasia (POH) is a progressive bone disorder in which bone forms (ossifies) within skin, subcutaneous and deep tissue, and muscle tissue. Ossification may cause pain and open sores (ulcers) in affected areas of the body. Joints may become involved over time, causing impaired mobility. POH is caused by a genetic change in the GNAS gene and is inherited in an autosomal dominant manner. In most cases, the genetic change occurs randomly in a person with no family history of POH. In some cases, the genetic change is inherited from a parent. POH is thought to be part of a spectrum of related genetic disorders which include Albright hereditary osteodystrophy, pseudohypoparathyroidism, and primary osteoma cutis. These disorders share the features of superficial ossification and being caused by genetic changes affecting the GNAS gene.